now unable to access or change any options. Placing the game settings menus in the middle of the screen = BAD idea. In windowed mode, with of course the game defaulting to use both screens places the menu squarely in the middle... with the options choices unavailable. Is there a command to reset to default so I can at least get twinview big screen again? Or should I just uninstall and reinstall?

You can use alt-enter to switch between fullscreen and window mode.

If that isn't enough you can edit ~/.vendetta/config.ini to change options or delete it to reset your config.

For getting window mode to work with twinview this might be useful: http://www.vendetta-online.com/x/msgboard/6/20602?page=2#272134