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Bleh... nuclear bombs are so last millennium.

How about a hadron collider.

Now there's a doomsday device. Let's see if we can make it eat the planet!

Now we can add CERN to the list of evil organizations.

McAuley, Paul J. "How We Lost the Moon, A True Story By Frank W. Allen."

An excellent short story, related to particle colliders and the theoretical disasters they could create.